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Beilstein J. Org. Chem. 2014, 10, 1645–1650, doi:10.3762/bjoc.10.171
Graphical Abstract
Figure 1: Inhibitors of isoprene biosynthesis.
Figure 2: Biosynthesis of geranylgeranyl diphosphate.
Figure 3: A known inhibitor of GGDPS (5) and a new analogue (6).
Scheme 1: Synthesis of bisphosphonate ethers 6 and 11.
Scheme 2: Synthesis of prenyl/geranyl bisphosphonate isomers.
Scheme 3: Synthesis of citronellyl bisphosphonates.